|
KMID : 0620920210530071170
|
|
Experimental & Molecular Medicine
2021 Volume.53 No. 7 p.1170 ~ p.1179
|
|
|
S100A9 in adult asthmatic patients: a biomarker for neutrophilic asthma
|
|
Quoc Quang Luu
Choi Young-Woo
Bich Tra Cao Thi
Yang Eun-Mi
Shin Yoo-Seob
Park Hae-Sim
|
|
|
Abstract
|
|
|
|
The biomarkers and therapeutic targets of neutrophilic asthma (NA) are poorly understood. Although S100 calcium-binding protein A9 (S100A9) has been shown to correlate with neutrophil activation, its role in asthma pathogenesis has not been clarified. This study investigated the mechanism by which S100A9 is involved in neutrophil activation, neutrophil extracellular trap (NET)-induced airway inflammation, and macrophage polarization in NA. The S100A9 levels (by ELISA) in sera/culture supernatant of peripheral blood neutrophils (PBNs) and M0 macrophages from asthmatic patients were measured and compared to those of healthy controls (HCs). The function of S100A9 was evaluated using airway epithelial cells (AECs) and PBNs/M0 macrophages from asthmatic patients, as well as a mouse asthma model. The serum levels of S100A9 were higher in NA patients than in non-NA patients, and there was a positive correlation between serum S100A9 levels and sputum neutrophil counts (r?=?0.340, P?=?0.005). Asthmatic patients with higher S100A9 levels had lower PC20 methacholine values and a higher prevalence of severe asthma (SA) (P?
|
|
|
KEYWORD
|
|
|
Adaptive immunity, Diagnostic markers, Immunological disorders, Prognostic markers
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
    
|